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. 2021 Sep 29;22(19):10550. doi: 10.3390/ijms221910550

Figure 4.

Figure 4

BCP inhibited angiogenesis ex vivo and in vivo. Photomicrographs showing the anti-angiogenic effect of BCP on the sprouting of microvessels in the rat aortic ring assay after treatment with (0.5% DMSO), 10, and 20 µM BCP. Representative images were taken on the 5th day of the experiment using an inverted phase-contrast microscope at 4× magnifications with the scale indicating 200 µm (A). Photomicrographs showing anti-angiogenic effect of BCP against chick embryonic CAM assay. Representative images of BCP on neovascularization in the chorioallantoic membrane, where the white arrows indicate the growth of new blood vessels indicating angiogenesis (B). Effect of BCP on rat aortic ring assay (C). Effect of BCP on the chick embryonic CAM assay (D). The data were represented as the mean ± SD (n = 3). * p < 0.05 and ** p < 0.01 compared to DMSO-treated control group.