Figure 6.

Suppression of pro-inflammatory cytokines mRNA upregulation by isoprenoid analogues. MG6 cells were administered isoprenoid analogues (10 µM) for 24 h followed by LPS treatment (10 ng/mL) for 3 h. (a–d) Pro-inflammatory cytokine mRNA expression following pre-treatment with isoprenoid analogues. mRNA levels were measured via qRT-PCR, normalized to the level of Eef1a1 (the internal standard), and expressed as fold-changes relative to the LPS-only treated group. Data are presented as the mean ± S.E.M, n = 3; * p < 0.05 vs. LPS-only treatment group. GGOH, geranylgeraniol; FOH, farnesol; and POH, phytol.