Table 1.
Summary of differentially expressed miRNAs in parathyroid tumors.
| Candidate miRNAs |
Expression Levels | miRNA Expression Profiling Platform | AUC Value | Study |
|---|---|---|---|---|
| miR-26b, miR-30b, and miR-126* |
↓ | miRNA arrays, qPCR |
0.766 (miR-126*) for discriminating parathyroid adenoma from carcinoma | [29] |
| / | / | qPCR | / | [30] |
| miR-222, miR-503, miR-139, and miR-296 |
↑ and ↓ | Microarray, qPCR |
/ | [31] |
| C19MC miRNAs and miR-372 | ↑ | qPCR | / | [32] |
| miR-372 | ↑ | qPCR | / | [33] |
| miR-222, miR-30b, miR-126*, miR-139, and miR-517c |
↑ and ↓ | qPCR | 0.864 (miR-30b), 0.747 (miR-139), 0.888 (miR-30b + miR-139) for discriminating between PC patients and adenoma patients |
[34] |
| Serum exosomal miR-27a-5p | ↑ | NGS, qPCR |
0.8594 for discriminating PCs from adenoma |
[35] |
| miR-24-1 | ↑ | qPCR | / | [36] |
| miR-1301, miR-664, and miR-4258 |
↑ and ↓ | Microarray, qPCR |
0.65 (miR-4258), 0.84 (miR-1301), 0.92 (miR-664), 0.84 (miR-4258) for discriminating MEN1-LOH from MEN1-no-LOH PAs and control pool |
[37] |
| miR-199b-5p | ↓ | Microarray, qPCR |
0.863 for distinguishing between sporadic and hereditary parathyroid tumors | [38] |
| miR-17-5p, miR-135b-5p, miR-31-5p, miR-186-5p, miR-330-3p, miR-24-3p, and miR-29b-3p |
↑ and ↓ | Microarray, qPCR |
/ | [39] |
↑, increase in miRNA expression levels; ↓, reduction in miRNA expression levels.