Table 1.

The different classes of HDACs, the multiple DDR key-components and the specific DDR cellular pathways as their targets.

Class of Deacetylases		Impact on Components of DDR Pathways	DNA Damage Pathway
Class I	HDAC1 HDAC2 HDAC3 HDAC8	p-Glycoprotein, RAD51 TIP60	NHEJ, HR
Class IIA	HDAC4 HDAC5 HDAC7
Class IIB	HDAC6
Class III	SIRT1 SIRT6 SIRT7	APE1, WRN, PARP1, NBS1, DNA-PKs, CtIP, Ku70, XPA Ku70/ Ku80, BRCA1, Rad50, Rad51, DNA-PKcs, mre11 FANCD2, CHK1	NER, HR, NHEJ