Figure 1.

Effect of chrysin on cyclosporine A (CsA)-induced renal dysfunction. Male Sprague Dawley rats were treated with 25 mg/kg cyclosporine A (CsA) with or without 10 mg/kg or 50 mg/kg chrysin. (A) Serum creatinine, (B) creatinine clearance and (C) BUN levels measured on days 0 and 28 are shown. Data is represented as means ± SD with at least 5 animals per treatment group. Statistical significance was determined by one-way ANOVA followed by Tukey’s test for multiple comparisons. * indicates p < 0.05 versus control; # indicates p < 0.05 vs. CsA alone.