Table 4.
Most active human liver CYP isoforms metabolizing unsaturated PAs.
| PA Type | Most Active CYP Isoforms |
|---|---|
| Clivorine | CYP 3A4 |
| Integerrimine | CYP 3A4, CYP 3A5 |
| Lasiocarine | CYP 3A4, CYP 3A5 |
| Monocrotaline | CYP 2A6 |
| Retrorsine | CYP 2A6, CYP 3A4, CYP 3A5 |
| Riddelline | CYP 3A4, CYP 3A5 |
| Senecionine | CYP 2A6, CYP 3A4, CYP 3A5 |
| Seneciphylline | CYP 2A6, CYP 3A4, CYP 3A5 |
| Senkirkine | CYP 3A4 |
The most active CYP isoforms catalyze the formation of pyrrole protein adducts. Abbreviations: CYP, cytochrome P450; PA, pyrrolizidine alkaloid. Updated, adapted, and modified from a previous report by He et al. [172].