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(A): Effects of Oxacom (3 mg/kg or 0.1 μM/kg of DNIC-GS respectively) on mean arterial pressure (MAP) and heart rate (HR) of healthy male volunteers. (B): EPR signals of DNIC in the blood of healthy volunteers (a,b) and in solutions of M-DNICs with glutathione (c,d). Recordings were made at ambient temperature (a,d) or at 77K (b,c). (C): Pharmacokinetics of DNIC in human venous blood (M ± m, n = 14) [7]. (With permission).
