Figure 2.

MicroRNA-Regulated Changes in Calcium Cycling in Heart Diseases. Schematic overview summarizes miR-mediated regulation of key Ca²⁺ handling proteins in heart diseases. CaMKII, Ca²⁺/CaM-dependent kinase II; LTCC, L-type Ca²⁺ channel; MCU, Mitochondrial Ca²⁺ uniporter; NCX, Na⁺/Ca²⁺ exchanger; RYR2, Ryanodine receptor type-2; SERCA2a, Sarcoplasmic reticulum Ca²⁺-adenosine triphosphatase 2; and SUMO1, Small ubiquitin-like modifier type 1. Red solid arrow represents Ca²⁺-induced Ca²⁺ release. Blue solid arrow represents Ca²⁺ extrusion in diastolic relaxation. Dotted lines represent a positive or negative effect on the following molecules. Upregulated miRNAs represent in a red gradient-filled rounded rectangle. The varying expression changed miRNAs in heart disease represent in both blue and red gradient-filled rounded rectangles.