Table 1.

Associations between C-peptide or IS_HOMA and fatty acids classes are independent of BMI and leptin.

		Model 1			Model 2			Model 3
		β	CI	p	β	CI	p	β	CI	p
C-peptidea	Total fatty acids	−14.9	−201.4–171.7	0.875	−7.5	−202.1–187.1	0.939	−43.3	−243.0–156.5	0.669
	SFA	0.6	−66.0–67.3	0.985	6.5	−62.9–75.9	0.853	−0.7	−72.3–70.8	0.984
	MUFA	19.0	−38.3–76.3	0.512	21.2	−38.5–81.0	0.483	8.5	−52.7–69.8	0.783
	PUFA n-3	−17.0	−31.2–−2.8	0.019	−17.1	−32.0–−2.3	0.024	−21.5	−36.5–−6.4	0.006
	PUFA n-6	−17.5	−93.25–−58.3	0.648	−18.1	−97.1–61.0	0.652	−29.7	−110.8–−51.4	0.470
	Ratio n-6/n-3	0.69	0.12–1.25	0.018	0.69	0.10–1.28	0.022	0.78	0.17–1.38	0.012
ISHOMAa	Total fatty acids	35.0	−131.2–201.3	0.677	30.9	−142.1–203.8	0.677	69.6	−111.4–250.5	0.448
	SFA	10.5	−48.9–69.9	0.727	6.5	−55.2–68.1	0.836	14.4	−50.4–79.2	0.661
	MUFA	−8.5	−59.7–42.6	0.742	−9.1	−62.3–44.1	0.735	3.3	−52.3– 58.8	0.908
	PUFA n-3	15.1	2.5–27.8	0.020	15.2	2.0–28.3	0.025	20.1	6.4–33.7	0.004
	PUFA n-6	18.0	−49.6–85.5	0.599	18.4	−51.9–88.6	0.605	31.8	−41.6–105.3	0.392
	Ratio n-6/n-3	−0.59	−1.09–−0.09	0.022	−0–0.59	−1.12–−0.07	0.027	−0.69	−1.24–−1.14	0.014

Model 1: adjusted for gestational age, maternal age, and processing time. Model 2: Model 1 + BMI adjustment. Model 3: Model 1 + leptin adjustment. Bold: Statistically significant difference after correction for multiple testing (FDR = 0.2). β: β estimate; CI: 95% confidence interval. SFA: sum of 14:0, 16:0, and 18:0; MUFA: sum of 16:1, 18:1, and 22:1; n-3 PUFA: sum of 18:3, 20:3, 20:5, 22:5, and 22:6; n-6 PUFA: sum of 18:2, 18:3, 20:3, 20:4, 22:2, 22:4, and 22:5. An ln-transformed variable. Non-normally distributed variables were ln-transformed to meet the requirements of multivariate linear regression analysis. Each 1% increase in the predictor variable (C-peptide and ISHOMA) increases the outcome variable by 1/100 units of the estimate. For example, a 1% increase in C-peptide is associated with a 0.17 mg/L decrease in n-3 PUFA.