Figure 5.

Crosstalk and interplay between tumor and immune cells through metabolic reprogramming. This illustration shows that the reprogramming of certain metabolic pathways in tumor cells, such as glycolysis, can offer not only a survival advantage to the tumor cells, but can also change the behavior/function of immune cells. Similarly, the metabolic rewiring of immune cells can act on tumor cells reciprocally to facilitate tumor progression. The red arrows and text indicate enhanced metabolic processes, whereas the blue arrows and text indicate suppressed activities. The black arrows and text indicate baseline levels.