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. 2021 Sep 24;22(19):10280. doi: 10.3390/ijms221910280

Figure 7.

Figure 7

The YIGSR and cyclo(RGD) peptides derived from ECM proteins dampened the ability of CTX to increase vascular adhesiveness. (a) Schematics and sequences of the peptides. (b) Cancer cells were incubated with the YIGSR and cyclo(RGD) double peptides for 20 min before injection into mice pre-treated with CTX (+) or vehicle (−). Cancer cell number per FOV at 3 h after injection were analyzed (n = 8–9 from 2 independent experiments). Bottom: Representative images. (c) Same as in (b) except single peptide was used: YIGSR (top) and cyclo(RGD) (bottom) (n = 6–8 from 2 independent experiments). Scale bar, 50 μm. Bars indicate mean ± SEM; one-way ANOVA with post hoc Holm–Šídák correction; * p < 0.05; ** p < 0.01; ns: not significant.