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. 2021 Sep 30;22(19):10620. doi: 10.3390/ijms221910620

Figure 2.

Figure 2

CXCR4 is a direct target of NANOG in human and medaka. Bar graphs showing reporter activities. (a) Regulation of luciferase reporter by Ol-Nanog. Ol-Nanog activates expression of luciferase only when it binds to the binding site sequence of Ol-Cxcr4b number 1 but this activation is not observed when assays are performed with sequences 2 and 3 or mutated sequence 1. (b) Regulation of luciferase reporter by h-NANOG. h-NANOG activates expression of luciferase when it binds to the binding site sequence of h-CXCR4 but this activation is not observed when the binding sequence presents the mutation 2. Abbreviations: Seq, sequence; MUT, mutation; WT: wild type sequence. *** corresponds to p < 0.001.