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. 2021 Sep 30;22(19):10620. doi: 10.3390/ijms221910620

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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h-NANOG regulates human tumor cell migration through CXCR4. (a) Transwell membranes showing migrated cell nuclei stained with DAPI. (b) Bar graphs showing the number of cell that migrates in response of different conditions. Cells migrated in higher proportion attracted by a greater concentration of serum (10%, positive control), by the presence of SDF1, NANOG or both. The increased migration due to SDF1 or NANOG was inhibited by the presence of AMD3100 (AMD), a specific inhibitor of CXCR4 receptor. * corresponds to p < 0.001.