Table 2.

Percent inhibition of compound 12a-n over V600EBRAF at single dose (1 µM).

Comp.	% Inhibition at 1 µM 1	Comp.	% Inhibition at 1 µM 1
12a	30.35 ± 0.41	12h	49.54 ± 0.61
12b	75.17 ± 0.27	12i	97.81 ± 0.82
12c	70.55 ± 0.71	12j	88.14 ± 0.19
12d	69.28 ± 0.51	12k	73.81 ± 0.75
12e	98.24 ± 0.44	12l	98.75 ± 0.58
12f	55.21 ± 0.52	12m	51.26 ± 0.29
12g	82.11 ± 0.32	12n	41.27 ± 0.46
Sorafenib	84.57 ± 0.77

¹ Percent inhibition values presented as mean ± S.D. of two experiments.