Table 3.

IC₅₀ (µM) ¹ of the target compounds 12a–n over BRAF (wild-type), V600EBRAF and CRAF.

Comp.	BRAF (Wild Type)	V600EBRAF	CRAF
12a	3.250 ± 0.450	1.910 ± 0.140	2.980 ± 0.210
12b	1.510 ± 0.220	0.740 ± 0.051	1.340 ± 0.190
12c	1.380 ± 0.170	0.820 ± 0.024	1.490 ± 0.230
12d	1.790 ± 0.150	0.910 ± 0.019	2.10 ± 0.180
12e	1.250 ± 0.095	0.620 ± 0.031	1.140 ± 0.088
12f	1.980 ± 0.120	0.980 ± 0.020	1.670 ± 0.210
12g	1.530 ± 0.260	0.790 ± 0.042	1.480 ± 0.099
12h	2.320 ± 0.110	1.120 ± 0.098	2.140 ± 0.078
12i	1.330 ± 0.081	0.530 ± 0.022	0.980 ± 0.044
12j	1.130 ± 0.099	0.790 ± 0.051	1.020 ± 0.077
12k	1.530 ± 0.110	0.810 ± 0.056	0.990 ± 0.085
12l	0.940 ± 0.065	0.490 ± 0.061	0.840 ± 0.076
12m	1.460 ± 0.086	0.820 ± 0.048	0.960 ± 0.079
12n	3.540 ± 0.175	1.280 ± 0.144	1.780 ± 0.156
Sorafenib	ND	0.814 ± 0.071	0.910 ± 0.094

¹ Percent inhibition values are the mean ± S.D. of two separate experiments. Most potent values are bold.