Table 4.

IC₅₀ (µM) ¹ of the target compounds 12a–n over SK-MEL-5 and A375 cell lines.

Comp.	SK-MEL-5	A375
12a	20.45 ± 0.86	12.78 ± 0.41
12b	15.63 ± 0.37	10.54 ± 0.22
12c	17.58 ±0.49	10.95 ± 0.36
12d	19.67 ± 0.51	11.78 ± 0.71
12e	6.54 ± 0.18	2.89 ± 0.14
12f	18.74 ± 0.69	12.59 ± 0.44
12g	8.25 ± 0.12	7.22 ± 0.23
12h	11.28 ± 0.29	9.26 ± 0.16
12i	2.36 ± 0.21	1.95 ± 0.13
12j	12.88 ± 0.72	10.39 ± 0.24
12k	13.46 ± 0.39	11.98 ± 0.47
12l	2.02 ± 0.09	1.85 ± 0.11
12m	14.56 ± 0.71	13.13 ± 0.27
12n	17.85 ± 0.62	16.87 ± 0.81
Sorafenib	9.22 ± 0.81	5.25 ± 0.74

¹ Percent inhibition values are presented as the mean ± S.D. of two experiments. Most potent values are bold.