Figure 7.

In a control MSC cell line, the expression of P53 and PTEN increased during osteogenic differentiation (A). p53 and PTEN gene expression was lower in CCD os-fibroblasts compared to control os-fibroblasts (ND = (normal donor) (B). Accordingly, both p53 and PTEN protein levels were lower in CCD os-fibroblasts compared to ND os-fibroblasts (C). All analyses were performed (in MSC line or in samples from each participant) in three independent analyses in triplicate. Data are shown as mean ±standard deviation (SD). * p < 0.05.