Table 2.

IC₅₀ values against MCF-7, MDA-MB-231, and HaCaT cell lines for curcumin and its new derivatives.

	IC5O [µM] ± SD			Selectivity Index (SI)
	MCF-7	MDA-MB-231	HaCaT	HaCat/MCF-7	HaCaT/MDA-MB-231
Curcumin	37.36 ± 1.88	57.07 ± 6.23	19.44 ± 2.60	0.52	0.34
Compound 1	79.38 ± 1.92	>100	60.18 ± 5.82	0.75	<0.60
Compound 2	>100	60.76 ± 5.04	54.15 ± 3.67	<0.54	0.89
Compound 3	30.99 ± 6.16	84.23 ± 7.70	41.02 ± 1.43	1.32	0.49
Compound 4	64.38 ± 11.79	>100	15.31 ± 1.52	0.23	<0.15
Compound 5	25.30 ± 2.54	31.86 ± 1.07	41.24 ± 3.22	1.63	1.29
Compound 6	30.51 ± 4.11	11.80 ± 1.43	30.84 ± 7.63	1.01	2.61
Compound 7	42.76 ± 2.18	49.13 ± 6.62	16.78 ± 1.51	0.39	0.34
Compound 8	39.59 ± 2.18	37.80 ± 2.52	21.94 ± 3.61	0.55	0.58
Compound 9	>100	>100	10.50 ± 1.44	<0.11	<0.11
Compound 10	28.27 ± 1.56	>100	8.38 ± 3.80	0.30	<0.08
Compound 11	32.44 ± 3.44	92.34 ± 2.98	52.79 ± 6.86	1.63	0.57
Compound 12	>100	71.96 ± 1.82	18.13 ± 3.46	<0.18	0.25
Doxorubicin	0.41 ± 0.75 a	0.60 ± 0.36 a	2.72 b	6.63 d	4.53 d
Tamoxifen	24.76 ± 0.80 a	25.84 ± 1.60 a	22.00 ± 1.02 c	0.89 d	0.85 d

^a [29]; ^b [30]; ^c [31]; ^d SI calculated based on literature data.