Table 3.

Significant results of differential gene expression analysis in SAT and VAT from Ob-NAFLD vs. Ob groups.

	Ob (n = 24)			Ob-NAFLD (n = 24)
	Median	Percentile		Median	Percentile
Tissue Depot		25%	75%		25%	75%	FC	p-Value
SAT
CD68	0.834	0.546	1.158	1.224	0.831	1.707	1.42	0.0162
MRC1	0.0940	0.0615	0.147	0.158	0.0939	0.223	1.61	0.0117
MSR1	0.154	0.0742	0.218	0.211	0.162	0.367	1.71	0.0171
VEGFB	0.237	0.177	0.260	0.265	0.216	0.355	1.38	0.0321
ANGPT1	0.0256	0.0165	0.0331	0.0340	0.0254	0.0477	1.41	0.0269
P16	0.0307	0.0020	0.0496	0.0060	0.0013	0.0211	0.30	0.0264
LEP	0.707	0.570	0.915	1.240	0.624	1.764	1.75	0.0353
LEPR	0.382	0.215	1.090	0.220	0.188	0.280	0.36	0.0105
PGC1A	0.0067	0.0048	0.0074	0.0048	0.0026	0.0053	0.73	0.0167
TGFB1	0.135	0.103	0.160	0.184	0.137	0.265	1.70	0.0021
UCP2	0.283	0.194	0.443	0.460	0.344	0.570	1.44	0.0024
COL1A1	0.304	0.208	0.571	0.707	0.492	0.963	1.35	0.0036
COL4A1	1.592	1.232	1.876	2.205	1.726	3.081	1.55	0.0070
COL6A1	0.0117	0.0093	0.0166	0.0392	0.0134	0.0847	9.44	0.0023
TIMP3	1.320	0.757	1.956	0.836	0.623	0.987	0.48	0.0074
VAT
HIF1A	0.348	0.259	0.434	0.244	0.178	0.374	0.81	0.0373
ANGPT2	0.0273	0.0227	0.0388	0.0209	0.0130	0.0293	0.65	0.0246
P53	0.0762	0.0561	0.155	0.0507	0.0432	0.0613	0.49	0.0019
P16	0.0098	0.0026	0.0170	0.0052	0.0008	0.0096	0.35	0.0348
LEP	0.290	0.157	0.675	0.422	0.335	1.308	1.87	0.0182
MGLL	0.389	0.242	0.467	0.592	0.391	0.688	1.67	0.0038
ATG12	0.0558	0.0387	0.0707	0.0646	0.0513	0.0953	1.32	0.0309
CIDEA	0.0343	0.0262	0.0405	0.0191	0.0098	0.0348	0.63	0.0039

p-values were calculated using Welch’s t-test or Mann-Whitney test. SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; FC, fold change.