Table 3.
Naka-Rushton equation parameters in normal dogs and dog models of retinitis pigmentosa. Shown as mean ± SD.
| Naka-Rushton Parameters | Normal (n = 12 eyes of 6 dogs) | PDE6A−/− untreated (n = 17 eyes of 10 dogs) | PDE6A−/− gene therapy (n = 6 eyes of 6 dogs) | CNGB1−/− untreated (n = 11 eyes of 7 dogs) | CNGB1−/− gene therapy (n = 4 eyes of 3 dogs) |
|---|---|---|---|---|---|
| log Vm (μV) | 2.159 ± 0.193 | 1.283 ± 0.21 | 1.659 ± 0.211 | 1.869 ± 0.29 | 1.820 ± 0.211 |
| log K (cd.s/m2) | −2.4 ± 0.17 | −0.57 ± 0.591 | −2.333 ± 0.419 | 0.063 ± 0.262 | −2.184 ± 0.296 |
| n | 1.355 ± 0.194 | 1.054 ± 0.232 | 1.475 ± 0.356 | 1.162 ± 0.258 | 1.327 ± 0.213 |