Table 2.

Phenotypes sharing association with variants also associated with severe COVID-19 infection, with reduced odds of disease listed in order of p-value^*.

Phenotype	OR (95% Cl)	p-value	Gene	SNP	COVID-severity
Psoriasis	0.89 [0.86–0.91]	6.48E-23	TYK2	rsll085727	Both
Rosacea	0.84 [0.8–0.89]	7.54E-16	HLA-DPB1	rs9501257	Critical
Psoriatic arthropathy	0.82 [0.77–0.88]	6.97E-12	TYK2	rsll085727	Both
Post-inflammatory pulmonary fibrosis	0.87 [0.83–0.92]	4.54E-09	NSF	rs9896243	Critical
Vitiligo	0.69 [0.56–0.82]	3.03E-08	CCHCR1	rslll837807	Both
Sarcoidosis	0.74 [0.62–0.85]	1.80E-07	CCHCR1	rslll837807	Both
Lupus (localized and systemic)	0.84 [0.77–0.91]	3.97E-06	TYK2	rsll085727	Both
Cutaneous lupus erythematosus	0.79 [0.68–0.89]	6.21E-06	TYK2	rsll085727	Both
Post-inflammatory pulmonary fibrosis	0.85 [0.8–0.9]	2.26E-12	CRHR1	rs61667602	Hospitalized
Rheumatoid arthritis	0.84 [0.79–0.9]	4.20E-10	HLA-DRA	rs9268576	Hospitalized
Idiopathic fibrosing alveolitis	0.81 [0.73–0.88]	1.58E-08	CRHR1	rs61667602	Hospitalized
Rheumatoid arthritis and other inflammatory polyarthropathies	0.88 [0.84–0.93]	6.34E-08	HLA-DRA	rs9268576	Hospitalized
Other alveolar and parietoalveolar pneumonopathy	0.88 [0.83–0.93]	7.50E-07	CRHR1	rs61667602	Hospitalized

^*OR<0.9 and P<10–5 shown in table, full results in supplementary; if multiple related conditions, e.g. psoriasis, psoriasis vulgaris, psoriasis and related disorders, description with lowest p-value selected shown in table.