Comparison 4. Symptoms.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 Pain	9	2386	Std. Mean Difference (IV, Random, 95% CI)	‐0.00 [‐0.09, 0.08]
4.2 Fatigue	4	741	Std. Mean Difference (IV, Random, 95% CI)	0.03 [‐0.29, 0.36]
4.3 Dysponea	5	765	Std. Mean Difference (IV, Random, 95% CI)	‐0.11 [‐0.32, 0.11]
4.4 Cough	2	122	Std. Mean Difference (IV, Random, 95% CI)	‐0.14 [‐0.75, 0.48]
4.5 Nausea	2	239	Std. Mean Difference (IV, Random, 95% CI)	‐0.08 [‐0.76, 0.59]
4.6 Depressive symptoms	16	3449	Std. Mean Difference (IV, Random, 95% CI)	‐0.12 [‐0.19, ‐0.05]
4.7 Anxiety symptoms	8	2334	Std. Mean Difference (IV, Random, 95% CI)	‐0.17 [‐0.31, ‐0.03]
4.8 Insomnia	2	202	Mean Difference (IV, Random, 95% CI)	‐3.10 [‐14.77, 8.57]
4.9 Anorexia	2	202	Std. Mean Difference (IV, Random, 95% CI)	‐0.09 [‐0.37, 0.19]
4.10 Constipation	2	202	Std. Mean Difference (IV, Random, 95% CI)	0.14 [‐0.14, 0.42]
4.11 Diarrhoea	2	202	Std. Mean Difference (IV, Random, 95% CI)	‐0.05 [‐0.33, 0.22]