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. 2021 Oct 1;22(19):10678. doi: 10.3390/ijms221910678

Figure 3.

Figure 3

mRNA expressions of DNMTs, HDACs, MeCP2, and TETs in the hippocampus of SI-AGG and GH mice. Increased mRNA of HDAC1 and MeCP2 (Unpaired t test two-tailed: HDAC1: * p = 0.01; t = 2.96; df = 14; n = 8; MeCP2: * p = 0.01; t = 2.81; df = 13; n = 7–8) and decreased expression of TET2 (* p = 0.02; t = 2.46; df = 14; n = 8) were found in the hippocampus of SI-AGG mice, whereas no changes were detected in the mRNA of the DNMT enzymes. This evidence corroborates our finding supporting stress-induced epigenetic alterations leading to a PPAR-α gene hypermethylation and a decreased expression in the hippocampus of SI-AGG mice.