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. 2021 Oct 7;22(19):10847. doi: 10.3390/ijms221910847

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Licochalcone A inhibited KCa3.1 currents (I_KCa3.1) in KCa3.1-overexpressing HEK293 cells. (A) A typical I_KCa3.1 trace and I-V relationship demonstrates the effect of 3 µM licochalcone A on I_KCa3.1 in KCa3.1-overexpressing HEK293 cells following treatment with TRAM-34 (1 µM), a selective blocking agent of the KCa3.1 channel. (B) A whole-cell trace and I-V relationships of I_KCa3.1 in the cells treated with 10 µM licochalcone A and TRAM-34. (C) An IC₅₀ value for licochalcone A suppression of I_KCa3.1 in the cells. Data are presented as means ± SEM (n = 3–4 per dose).