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. 2021 Oct 6;22(19):10803. doi: 10.3390/ijms221910803

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PDB entries containing at least one α-thrombin chain: (a) the cumulative temporal growth of these structures and (b) the number of structures deposited per year. Structures were selected by considering all PDB entries released within 2020 containing at least one chain with a sequence identity higher than 75% when compared with α-thrombin (Uniprot code: P00734). Considering the length of the thrombin (295 residues), in order to exclude protein fragments and precursors, the ensemble content was further refined by considering polypeptide chains with a number of residues comprised between 200 and 300. This survey yielded a structural ensemble of 451 structures from the following species: Homo sapiens (421 structures), Bos Taurus (23), and Mus Musculus (7).