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. 2021 Oct 3;22(19):10732. doi: 10.3390/ijms221910732

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Platelet activation at the maternal-fetal interface. Scheme of a first trimester placental villus shows adherent platelets on fibrin deposition and on extracellular matrix on areas of disrupted villous trophoblasts. Activated platelet show relevant surface receptors. CT: cytotrophoblast; SCT: syncytiotrophoblast; ECM: extracellular matrix; PLT: platelet; TXA₂: thromboxane A₂; ADP: adenosine diphosphate; TGF-β: transforming growth factor beta; vWF: von Willebrand factor; TP: thromboxane receptor.