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. 2021 Oct 6;10(19):4598. doi: 10.3390/jcm10194598

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antero-posterior (AP) dimension in the ROC analysis of the chance for incorrect diagnosis of pituitary lesions in a conventional MRI examination in children with growth or puberty disorders. The receiver operating characteristic (ROC) analysis shows that the antero-posterior (AP) dimension is a statistically significant (area under curve [AUC] lower CI 95% > 50%) predictor of the appropriateness of contrast administration in the diagnosis of pituitary focal lesions in children with growth or puberty disorders (GPDs). Classification of pa-tients based on the AP cut-off = 7.5 mm indicates proper post-contrast diagnosis in (AUC∼73%=) 3 out of 4 patients. Furthermore, ROC analysis of the AP dimension testifies the best fitted combination of sensitivity (69%) and specificity (74%) rates, which reveals the high ability of this predictor to use gadolinium-based contrast agent (GBCA) correctly when required, and the proper omission of GBCA administration when unnecessary.