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Schematic representation of the average duration of Alzheimer’s clinical course that has been reported for the sporadic form of the disease (LOAD) [67], the familial one (PSEN1, PSEN2, APP and dAPP) [68]; and AD in the DS population (DS) [61]. * The mean age of death for LOAD was calculated from the mean age at onset plus the average survival; LOAD = Late-onset Alzheimer’s disease.
