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. 2021 Oct 7;22(19):10848. doi: 10.3390/ijms221910848

Figure 5.

Figure 5

General regions extracted in principal component analyses. (A) The PCA of the number of c-Fos positive nuclei in a brain nucleus of revealed two independent dimensions (factors): Factor 1 and Factor 2. (B) Factor 1 was obtained from measures registered in habenula lateral (LHb), habenula medial (mHb), ventral tegmental area (VTA), and dorsal raphe (DR). Factor 2 was obtained from measures registered in dentate gyrus (DG) and prefrontal cortes (PFC). A brain nucleus was considered to be included in a factor when its loading was > 0.5 in absolute value (highlighted in bold). (C,D) Data represent the mean of the factor scores of the subjects in each one of the networks ± SEM of Factor 1 and 2 in SHAM SS+aCSF, OBX SS+aCSF, OBX ESC10 mg+aCSF, and OBX ESC10 mg+GAL(1-15)(1 nmol) (n = 4–5 rats per group). In Factor 1 there are no significant differences according to one way ANOVA followed by Fisher multiple comparison test. In Factor 2 * p < 0.05 versus OBX SS+aCSF and ** p < 0.01 versus OBX ESC10mg+aCSF according to one way ANOVA followed by Fisher multiple comparison test.