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. 2021 Oct 7;22(19):10848. doi: 10.3390/ijms221910848

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Diagram of the complete experimental schedule. (A) After, bilateral olfactory bulbectomy, all animals had a recovery period of 14 days and then we determine their hyperactivity using the open field test (OFT). One set of animals were randomly selected and their brains were collected to perform the experiments of qPCR-rt. In other set of animals, we evaluated the effects of different pharmacological treatments in the forced swimming test (FST) or tail suspension test (TST). After the behavioural tests we collected the brain of the animals to perform the experiments of immunohistochemistry. (B) after bilateral olfactory bulbectomy, all animals had a recovery period of 14 days and then we determine their hyperactivity using the open field test. After we injected siRNA 5HT1A or delivery media and all animals had a recovery period of 14 days and then we evaluated the effects of different pharmacological treatments in the FST.

Diagram of the complete experimental schedule. (A) After, bilateral olfactory bulbectomy, all animals had a recovery period of 14 days and then we determine their hyperactivity using the open field test (OFT). One set of animals were randomly selected and their brains were collected to perform the experiments of qPCR-rt. In other set of animals, we evaluated the effects of different pharmacological treatments in the forced swimming test (FST) or tail suspension test (TST). After the behavioural tests we collected the brain of the animals to perform the experiments of immunohistochemistry. (B) after bilateral olfactory bulbectomy, all animals had a recovery period of 14 days and then we determine their hyperactivity using the open field test. After we injected siRNA 5HT1A or delivery media and all animals had a recovery period of 14 days and then we evaluated the effects of different pharmacological treatments in the FST.