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Diabetes-induced mechanical hyperalgesia in Wistar rats, the mechanical nociceptive threshold of pressure sensitivity by Randall-Selitto test (a) and touch sensitivity by dynamic plantar aesthesiometer (DPA) test (b). Data are presented as means ± SEM of 5/6 rats/group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle-treated diabetic group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. PACAP-treated diabetic group, & p < 0.05 vs. vehicle-treated diabetic group.
