Table 3.

The results obtained in PAMPA for 5-HT₆R ligands and the reference caffeine (CFN).

Cpd	a,bPe (10−6 cm/s) ± SD
CFN	15.1 ± 0.4
1	18.9 ± 0.9 c
2	20.5 ± 5.4
3	15.1 ± 1.0

^a PAMPA plate’s manufacturer breakpoint for permeable compounds: Pe ≥ 1.5 × 10⁻⁶ cm/s [22]; ^b tested in triplicate; ^c Pe value revealed in previous studies [21].