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The results obtained in a bi-directional Caco-2 permeability assay for 5-HT6R ligands and the reference.
| Cpd | aPapp (10−6 cm/s) ± SD | b Efflux Ratio | |
|---|---|---|---|
| A-B | B-A | ||
| CFN | 15.6 ± 0.55 | 17.9 ± 1.9 | 1.14 |
| 1 | 14.2 ± 0.36 | 22.2 ± 1.92 | 1.56 |
| 2 | 50.3 ± 6.22 | 21.1 ± 2.14 | 0.42 |
| 3 | 3.16 ± 1.35 | 10.1 ± 0.15 | 3.20 |
a Papp, Apparent permeability coefficient, test permeability for each compound was tested in triplicate, data are mean ± standard deviation. b The quotient of mean Papp for B-A to the mean Papp for A-B.
