Table 6.
The mutagenicity potential of 1–3, reference mutagen nonyl-4-hydroxyquinoline-N-oxide (NQNO, 0.5 µM).
| Conc. (µM) | Compound | Fold Increase over MCB a | Binomial B-Value b | Number of Revertants ± SD |
|---|---|---|---|---|
| 0.5 | NQNO | 3.23 | 1.0000 | 48.00 ± 0.00 |
| 1 | 2 | 0.81 | 0.2601 | 12.00 ± 7.55 |
| 10 | 2 | 0.90 | 0.5425 | 13.33 ± 2.31 |
| 0.25 | NQNO | 7.02 | 1.0000 | 40.33 ± 4.04 |
| 1 | 1 | 0.35 | 0.0707 | 2.00 ± 1.00 |
| 10 | 1 | 0.35 | 0.0707 | 2.00 ± 1.00 |
| 1 | 3 | 0.06 | 0.0001 | 0.33 ± 0.58 |
| 10 | 3 | 0.29 | 0.0324 | 1.67 ± 1.53 |
a Fold increase over MCB (baseline)values ≥ 2.0 scores individual doses as positive. MCB (baseline) means positive wells+1SD in the control. b Binomial B-value indicates the probability that spontaneous mutation events alone. The result ≥0.99 indicates that chances of spontaneous mutation are ≤1%.