Table 8.
Mean values of pharmacokinetic parameters calculated from the concentrations of 2 and 3 compounds in serum and tissues after single i.p. administration at a dose of 0.3 mg/kg (non-compartmental analysis) (n = 4/time point).
| 2 | ||||
|---|---|---|---|---|
| Tissue | Tmax (min) |
Cmax (ng/mL or ng/g) |
AUC0-t (ng·min/mL or ng·min/g) |
Kp |
| Serum | 15 | 5.20 ± 2.24 | 453.40 ± 145.83 | - |
| Brain | 5 | 11.63 ± 3.13 | 1219.94 ± 368.79 | 2.69 |
| Heart | 5 | 8.90 ± 8.15 | 1040.74 ± 448.65 | 2.30 |
| Lungs | 5 | 54.20 ± 21.61 | 3870.66 ± 680.07 | 8.54 |
| Liver * | 15 | 115.22 ± 93.46 | 6523.60 ± 4997.28 | 14.39 |
| Kidneys | 15 | 65.73 ± 34.94 | 7488.06 ± 4372.92 | 16.52 |
| 3 | ||||
| Serum | 5 | 6.32 ± 5.04 | 423.91 ± 216.75 | - |
| Brain | 5 | 11.35 ± 6.93 | 859.08 ± 312.87 | 2.03 |
| Heart | 5 | 21.83 ± 17.16 | 1057.37 ± 285.41 | 2.49 |
| Lungs | 5 | 73.65 ± 63.94 | 2715.09 ± 1000.42 | 6.41 |
| Liver * | 5 | 129.62 ± 106.23 ** | 4467.18 ± 2249.99 | 10.54 |
| Kidneys | 15 | 41.25 ± 8.41 | 2557.08 ± 1084.42 | 6.03 |
Cmax—maximum concentration; Tmax—time to reach the maximum concentration; Kp—ratio of AUC0-t tissue to AUC0-t serum. * Cmax ratio (2/3) = 0.89. ** Expressed with molar concentration: Cmax = 0.395 µM.