Table 9.
The effect of compounds 2 and 3 on the exploration activity of rats in the NOR test 1.
| Treatment | Dose (mg/kg) | Total Exploratory Time in T2 Session (s) |
|---|---|---|
| Vehicle + vehicle | 0 + 0 | 58.71 ± 3.38 |
| MK-801 + vehicle | 0.1 + 0 | 42.00 ± 3.13 |
| 2 + MK-801 | 0.3 + 0.1 | 52.67 ± 5.37 |
| 1 + 0.1 | 40.33 ± 6.66 | |
| 3 + 0.1 | 42.88 ± 2.10 F(4,27) = 3.5450; p < 0.05 |
|
| vehicle | 0 + 0 | 45.00 ± 4.30 |
| MK-801 + vehicle | 0.1 + 0 | 47.07 ± 3.89 |
| 3 + MK-801 | 0.1 + 0.1 | 47.33 ± 4.79 |
| 0.3 + 0.1 | 38.14 ± 4.18 | |
| 1 + 0.1 | 35.57 ± 3.76 | |
| 3 + 0.1 | 34.14 ± 1.22; F(5,47) = 1.9394; NS |
1 Compounds 2 and 3 were given i.p. 60 min, while MK-801 was injected i.p. 30 min before the test. Values represent the mean ± SEM of the total exploratory time of both objects during the 3-min test session (T2) compared to the respective vehicle group (one-way ANOVA followed by Bonferroni’s post-hoc test); NS—non-significant. N = 6–7.