Table 10.
Effect of compounds 1, 2, 3 on total exploration in the EPM test in rats 1.
Treatment | Dose (mg/kg) | Total Distance (cm) | X Ambulation | Y Ambulation |
---|---|---|---|---|
Vehicle | 0 | 4600 ± 140 | 175 ± 7 | 104 ± 10 |
1 | 1 | 4520 ± 168 | 172 ± 6 | 99 ± 6 |
3 | 3995 ± 218 | 146 ± 10 | 82 ± 7 | |
10 | 3681 ± 256; p < 0.05 F(3,24) = 4.5291; p < 0.05 |
140 ± 11 F(3,24) = 3.8035; p < 0.05 |
83 ± 8 F(3,24) = 1.9215; NS |
|
Vehicle | 0 | 3639 ± 327 | 137 ± 19 | 81 ± 12 |
2 | 0.3 | 4372 ± 132 | 180 ± 9 | 101 ± 9 |
1 | 3987 ± 281 | 149 ± 18 | 78 ± 9 | |
3 | 4595± 191 F(3,23) = 2.9772; NS |
168 ± 6 F(3,23) = 1.9417; NS |
115 ± 7 F(3,23) = 3.1727; NS |
|
Vehicle | 0 | 3639 ± 327 | 137 ± 19 | 81 ± 12 |
3 | 0.3 | 4033 ± 340 | 151 ± 16 | 80 ± 8 |
1 | 4102 ± 291 | 136 ± 15 | 86 ± 10 | |
3 | 3545 ± 136 F(3,22) = 0.9071; NS |
123 ± 5 F(3,22) = 0.6336; NS |
73 ± 5 F(3,22) = 0.3805; NS |
1 Compounds 1–3 were given i.p. 60 min before the test. Values represent the mean ± SEM of the total distance, X ambulation, and Y ambulation during 5-min test session compared to the respective vehicle group (one-way ANOVA followed by Bonferroni’s post hoc test); NS—non-significant. N = 6–7.