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. 2021 Oct 5;22(19):10773. doi: 10.3390/ijms221910773

Table 10.

Effect of compounds 1, 2, 3 on total exploration in the EPM test in rats 1.

Treatment Dose (mg/kg) Total Distance (cm) X Ambulation Y Ambulation
Vehicle 0 4600 ± 140 175 ± 7 104 ± 10
1 1 4520 ± 168 172 ± 6 99 ± 6
3 3995 ± 218 146 ± 10 82 ± 7
10 3681 ± 256; p < 0.05
F(3,24) = 4.5291; p < 0.05
140 ± 11
F(3,24) = 3.8035; p < 0.05
83 ± 8
F(3,24) = 1.9215; NS
Vehicle 0 3639 ± 327 137 ± 19 81 ± 12
2 0.3 4372 ± 132 180 ± 9 101 ± 9
1 3987 ± 281 149 ± 18 78 ± 9
3 4595± 191
F(3,23) = 2.9772; NS
168 ± 6
F(3,23) = 1.9417; NS
115 ± 7
F(3,23) = 3.1727; NS
Vehicle 0 3639 ± 327 137 ± 19 81 ± 12
3 0.3 4033 ± 340 151 ± 16 80 ± 8
1 4102 ± 291 136 ± 15 86 ± 10
3 3545 ± 136
F(3,22) = 0.9071; NS
123 ± 5
F(3,22) = 0.6336; NS
73 ± 5
F(3,22) = 0.3805; NS

1 Compounds 13 were given i.p. 60 min before the test. Values represent the mean ± SEM of the total distance, X ambulation, and Y ambulation during 5-min test session compared to the respective vehicle group (one-way ANOVA followed by Bonferroni’s post hoc test); NS—non-significant. N = 6–7.