Table 10.

Effect of compounds 1, 2, 3 on total exploration in the EPM test in rats ¹.

Treatment	Dose (mg/kg)	Total Distance (cm)	X Ambulation	Y Ambulation
Vehicle	0	4600 ± 140	175 ± 7	104 ± 10
1	1	4520 ± 168	172 ± 6	99 ± 6
	3	3995 ± 218	146 ± 10	82 ± 7
	10	3681 ± 256; p < 0.05 F(3,24) = 4.5291; p < 0.05	140 ± 11 F(3,24) = 3.8035; p < 0.05	83 ± 8 F(3,24) = 1.9215; NS
Vehicle	0	3639 ± 327	137 ± 19	81 ± 12
2	0.3	4372 ± 132	180 ± 9	101 ± 9
	1	3987 ± 281	149 ± 18	78 ± 9
	3	4595± 191 F(3,23) = 2.9772; NS	168 ± 6 F(3,23) = 1.9417; NS	115 ± 7 F(3,23) = 3.1727; NS
Vehicle	0	3639 ± 327	137 ± 19	81 ± 12
3	0.3	4033 ± 340	151 ± 16	80 ± 8
	1	4102 ± 291	136 ± 15	86 ± 10
	3	3545 ± 136 F(3,22) = 0.9071; NS	123 ± 5 F(3,22) = 0.6336; NS	73 ± 5 F(3,22) = 0.3805; NS

¹ Compounds 1–3 were given i.p. 60 min before the test. Values represent the mean ± SEM of the total distance, X ambulation, and Y ambulation during 5-min test session compared to the respective vehicle group (one-way ANOVA followed by Bonferroni’s post hoc test); NS—non-significant. N = 6–7.