Table 2.
Comparisons of NLR values according to OM grade, evaluation of diagnostic usefulness of NLR values in predicting the occurrence of more severe OM after subsequent weeks of RT.
| RT Week | OM Grade | Comparisons | ROC Curve Analysis | ||||
|---|---|---|---|---|---|---|---|
| NLR Median (Interquartile Range) | p | Cut-Off Value |
Sensitivity | Specificity | AUC [95% CI] p |
||
| 1 | 0 | 1.24 (1.03–1.61) | 0.1029 | >1.61 | 56.7% | 100% | 0.74 [0.67–0.80] 0.0012 * |
| 1 | 1.79 (0.01–34.30) | ||||||
| 2 | 1 | 1.69 (0.01–15.90) | 0.0225 * | >2.49 | 37.7% | 79.2% | 0.59 [0.52–0.66] 0.0204 * |
| 2 | 1.94(0.66–34.30) | ||||||
| 3 | 1 or 2 | 1.75 (1.21–2.49) | 0.0005 * | >2.59 | 87.5% | 78.4% | 0.67 [0.60–0.73] <0.0001 * |
| 3 | 4.76 (2.70–7.69) | ||||||
| 4 | 1 or 2 | 1.72 (0.01–34.30) | 0.0159 * | >2.49 | 72.7% | 75.5% | 0.72 [0.65–0.78] 0.0041 * |
| 3 | 2.60 (1.30–8.00) | ||||||
| 5 | 1 or 2 | 1.70 (0.01–34.30) | <0.0001 * | >2.63 | 55.9% | 85% | 0.73 [0.66–0.79] <0.0001 * |
| 3 or 4 | 2.80 (1.02–9.60) | ||||||
| 6 | 1 or 2 | 1.60 (0.01–34.30) | <0.0001 * | >2.52 | 59.3% | 87.6% | 0.78 [0.72–0.83] <0.0001 * |
| 3 or 4 | 2.74 (1.11–12.40) | ||||||
| 7 | 1 or 2 | 1.60 (0.01–15.90) | <0.0001 * | >2.1 | 60.3% | 72.4% | 0.68 [0.61–0.74] <0.0001 * |
| 3 | 2.35 (0.80–34.30) | ||||||
| 1–7 | 0, 1 or 2 3 or 4 |
1.60 (1.17–2.10) 2.35 (1.39–3.31) |
<0.0001 * | >2.06 | 59.8% | 75% | |
Abbreviations: AUC: area under curve, CI: confidence interval, NLR: neutrophil to lymphocyte ratio, OM: oral mucositis, ROC: receiver operating characteristic. * statistically significant result.