Table 5.
Clinical, hemodynamic data and therapeutic management of patients with CTEPH according to their operability. Categorical variables are presented as frequency and percentage, n (%).
| n = 74 | Operable n = 34 | Non-Operable n = 40 | p-Value * |
|---|---|---|---|
| Subjects | 34 (45.9) | 40 (54.1) | |
| Female | 16 (21.6) | 27 (36.5) | 0.099 |
| Age, years | 53 ± 13 | 63 ± 15 | <0.0001 |
| BMI, (kg/m2) | 27.0 (8.2) | 27.1 (5.7) | 0.542 |
| WHO FC | |||
| I | 5 (14.7) | 1 (2.5) | 0.037 |
| II | 18 (52.9) | 16 (40) | |
| III | 10 (29.4) | 23 (57.5) | |
| IV | 1 (2.9) | 0 | |
| 6-MWD, m | 420 (202) | 347 (206) | 0.278 |
| NT-proBNP, pg/mL | 570 (1706) | 814.0 (1949) | 1.0 |
| Right heart catheterization | |||
| mRAP, mmHg | 8.0 (6.8) | 8.5 (8.0) | 0.557 |
| mPAP, mmHg | 47.5 (20.5) | 44 (22) | 0.792 |
| PAWP, mmHg | 10.0 (4.8) | 12 (3.0) | 0.758 |
| CO, L/min | 4.2 ± 0.8 | 4.8 ± 1.7 | 0.385 |
| CI, L/min/m2 | 2.3 ± 0.4 | 2.6 ± 0.9 | 0.357 |
| PVR, WU | 9.1 (5.7) | 6.8 (6.7) | 0.536 |
| HR, bpm | 74 ± 8 | 78 ± 10 | 0.091 |
| SVO2, % | 64.9 ± 8.9 | 63.6 ± 10 | 0.375 |
| V/Q scintigraphy (abnormal) | 14 (18.9) | 13 (17.6) | 0.511 |
| Chest CTPA | 19 (55.9) | 13 (32.5) | 0.062 |
| Central thrombi | 13 (38.2) | 2 (5) | 0.008 |
| Peripheral thrombi | 10 (29.4) | 10 (25) | 0.686 |
| Pulmonary Angiography | 19 (55.9) | 21 (52.5) | 0.818 |
| Supportive Therapy | |||
| Oxygen therapy | 10 (29.4) | 15 (37.5) | 0.622 |
| Diuretics | 14 (18.9) | 21 (52.5) | 0.359 |
| OAC | 27 (79.4) | 23 (57.5) | 0.051 |
Continuous variables are presented as mean value ± standard deviation (SD) or median value with interquartile range (IQR). * Statistical significance between operable and inoperable patients with CTEPH: p < 0.05. CTEPH: Chronic Thromboembolic Pulmonary Hypertension; BMI: Body Mass Index; WHO: World Health Organization; FC: Functional Class; 6-MWD: Six-minute Walk Distance; NT-proBNP: N-terminal pro-brain natriuretic peptide; mRAP: mean Right Atrial Pressure; mPAP: mean Pulmonary Artery Pressure; PAWP: Pulmonary Artery Wedge Pressure; CO: Cardiac Output; CI: Cardiac Index; PVR: Pulmonary Vascular Resistance; WU: Wood Units; HR: Heart Rate; bpm: beats per minute; SvO2: oxygen saturation in pulmonary artery; CTPA: Combuted Tomography Pulmonary Angiography, OAC: Oral Anticoagulant.