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. 2021 Oct 8;22(19):10880. doi: 10.3390/ijms221910880

Figure 1.

Figure 1

P-AscH− enhances DNA damage induced by ionizing radiation (IR) in GBM cells, as seen by activation of γH2AX. (A) Catalase activity is increased by ≈8-fold in catalase-overexpressing U87 cells. * p < 0.05. Doxy (doxycycline) initiates the cellular overexpression of catalase. (B) IR + ascorbate increases DNA damage, as seen by normalized γH2AX expression in U87 cells. Ascorbate concentrations were 10 pmol/cell (2 mM). The dose of IR was 4 Gy. Doxycycline treatment was 1 μg/mL. Unpaired Student’s t-test was used to compare IR + P-AscH− with control, * p < 0.05.