Table A1.
Search strategy in Embase.
| Search | Query | Results |
|---|---|---|
| #1 | ‘non-small cell lung cancer’/exp OR ‘bronchial non-small cell cancer’ OR ‘bronchial non-small cell carcinoma’ OR ‘lung non-small cell cancer’ OR ‘lung non-small cell carcinoma’ OR ‘microcellular lung carcinoma’ OR ‘pulmonary non-small cell cancer’ OR ‘pulmonary non-small cell carcinoma’ OR ‘non-small cell bronchial cancer’ OR ‘non-small cell bronchial carcinoma’ OR ‘non-small cell cancer, lung’ OR ‘non-small cell lung cancer’ OR ‘non-small cell lung carcinoma’ OR ‘non-small cell pulmonary cancer’ OR ‘non-small cell pulmonary carcinoma’ | 171,940 |
| #2 | ‘NSCLC’:ab,ti OR ‘nsclc’:ab,ti OR ((non NEAR/3 ‘small cell ‘ NEAR/3 lung NEAR/3 cancer):ab,ti) OR ((non NEAR/3 ‘small cell’ NEAR/3 lung NEAR/3 carcinoma):ab,ti) OR ((non NEAR/3 ‘small cell ‘ NEAR/3 lung NEAR/3 neoplasm):ab,ti) | 115,898 |
| #3 | ((‘ large cell ‘ NEAR/3 lung NEAR/3 cancer):ab,ti) OR ((‘ large cell ‘ NEAR/3 lung NEAR/3 carcinoma):ab,ti) OR ((‘ large cell ‘ NEAR/3 lung NEAR/3 neoplasm):ab,ti) OR ((squamous NEAR/3 lung NEAR/3 cancer):ab,ti) OR ((squamous NEAR/3 lung NEAR/3 carcinoma):ab,ti) OR ((squamous NEAR/3 lung NEAR/3 neoplasm):ab,ti) OR ((adenocarcinoma NEAR/3 lung NEAR/3 cancer):ab,ti) OR ((adenocarcinoma NEAR/3 lung NEAR/3 carcinoma):ab,ti) OR ((adenocarcinoma NEAR/3 lung NEAR/3 neoplasm):ab,ti) | 11,061 |
| #3 | #1 OR #2 OR #3 | 182,051 |
| #4 | ((‘anaplastic lymphoma kinase ‘ NEAR/3 inhibit*):ab,ti) OR ((‘anaplastic lymphoma kinase ‘ NEAR/3 antagonist*):ab,ti) OR ((‘ALK ‘ NEAR/3 inhibit*):ab,ti) OR ((‘ALK ‘ NEAR/3 antagonist*):ab,ti) OR ((‘alk ‘ NEAR/3 inhibit*):ab,ti) OR ((‘alk ‘ NEAR/3 antagonist*):ab,ti) OR ((‘ALKI’):ab,ti) OR ((‘ALKIS’):ab,ti) | 3841 |
| #5 | crizotinib:ab,ti OR ‘pf 02341066’:ab,ti OR ‘pf 1066’:ab,ti OR ‘pf 2341066’:ab,ti OR pf02341066:ab,ti OR pf1066:ab,ti OR pf2341066:ab,ti OR xalkori:ab,ti OR ceritinib:ab,ti OR ‘ldk 378’:ab,ti OR ldk378:ab,ti OR ‘nvp ldk 378’:ab,ti OR ‘nvp ldk 378 nx’:ab,ti OR ‘nvp ldk378’:ab,ti OR ‘nvp ldk378 nx’:ab,ti OR zykadia:ab,ti OR alectinib:ab,ti OR ‘af 802’:ab,ti OR af802:ab,ti OR alecensa:ab,ti OR ‘alectinib hydrochloride’:ab,ti OR ‘ch 5424802’:ab,ti OR ch5424802:ab,ti OR ‘rg 7853’:ab,ti OR rg7853:ab,ti OR ‘ro 5424802’:ab,ti OR ro5424802:ab,ti OR brigatinib:ab,ti OR ‘ap 26113’:ab,ti OR ap26113:ab,ti OR lorlaninib:ab,ti OR ‘pf 06463922’:ab,ti OR lorlatinib:ab,ti OR ensartinib:ab,ti OR ‘unii sma5zs5b22’:ab,ti OR ‘370651 20 9’:ab,ti OR entrectinib:ab,ti OR ‘nms e 628’:ab,ti OR ‘nms e628’:ab,ti OR ‘rxdx 101’:ab,ti OR rxdx101:ab,ti | 5932 |
| #6 | #4 OR #5 | 7335 |
| #7 | #3 AND #6 | 4922 |
| #8 | ‘clinical trial’/de OR ‘randomized controlled trial’/de OR ‘randomization’/de OR ‘single blind procedure’/de OR ‘double blind procedure’/de OR ‘crossover procedure’/de OR (‘randomi?ed controlled’ NEXT/1 trial*) OR rct OR ‘randomly allocated’ OR ‘allocated randomly’ OR ‘random allocation’ OR (allocated NEAR/2 random) OR (single NEXT/1 blind*) OR (double NEXT/1 blind*) OR ((treble OR triple) NEAR/1 blind*) | 1,760,209 |
| #9 | #7 AND #8 | 793 |
| #10 | #9 NOT ([adolescent]/lim OR [child]/lim OR [preschool]/lim OR [school]/lim) | 786 |
* is truncation function in Embase.