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. 2021 Oct 5;22(19):10757. doi: 10.3390/ijms221910757

Figure 1.

Figure 1

Hallmark canonical pathways most consistently implicated in ASD molecular data. Datasets were collated from 19 studies and meta-analyses on ASD papers published between 2017 and 2021: six proteomic, eight transcriptomic and six DNA methylation (DNAm) studies. All gene lists were converted into NCBI Entrez gene IDs. Each dataset was annotated with respect to the top 10 significantly enriched Hallmark canonical pathways. The Hallmark canonical pathways that were significantly enriched in seven or more independent ASD proteomic, transcriptomic and DNAm datasets are shown; those shown in bold are those consistently implicated using all three molecular approaches.