aSMase	Acid sphingomyelinase
BBB	Blood–brain barrier
BM	Brain metastases
CAFs	Cancer associated fibroblasts
CEMIP	Cell migration-inducing and hyaluronan-binding protein
CNS	Central nervous system
CSCs	Cancer stem cells
CSF	Cerebrospinal fluid
CTCs	Circulating tumor cells
DCs	Dendritic cells
DDS	Drug-delivery system
ECM	Extracellular matrix
EMT	Epithelial–mesenchymal transition
ESCRT	Endosomal sorting complexes required for transport
EVs	Extracellular vesicles
HSP	Heat shock protein
ILVs	Intraluminal vesicles
MSCs	Mesenchymal stem cells
MSP	Muscle-specific peptide
MVs	Microvesicles
MVB	Multivesicular body
NSCLC	Non-small cell lung cancer
nSMase	Neutral sphingomyelinase
PMN	Pre-metastatic niche
RVG	Rabies viral glycoprotein
SCLC	Small cell lung cancer
TDEs	Tumor derived exosomes
TME	Tumor microenvironment
TRAIL	Tumor necrosis factor-related apoptosis-inducing ligand
UC	Ultracentrifugation
VEGF	Vascular endothelial growth factor