Table 2.

Effect of I. batatas on dyslipidemia.

Author	Type of Subject	Dosage of Treatment	Extraction Method	Follow up Duration	Findings	Conclusion
Park et al., 2012 [39]	Male Sprague Dawley rats fed with high-fat diet (HFD)	5% of total diet for 4 weeks	Fleshed	4th week	Increased level of total cholesterol and triglyceride content in fecal. Decreased level of total cholesterol and triglyceride content in serum. Decreased level of LDL-cholesterol level.	Sweet potato extraction is an effective agent to enhance fecal lipid excretion.
Jawi et al., 2015 [40]	Local Balinese male rabbits fed with high cholesterol diet	4 mL/kg/day for 60 days	Aqueous	60th day	Decreased level of total cholesterol in serum. Decreased level of MDA. Decreased level of interleukin-1 (IL-1) in blood.	Sweet potato extract is able to reduce cholesterol content.
Kurata et al., 2017 [41]	Male Sprague Dawley rats fed with HFD	0%, 1%, 3%, and 5% of total diet for 35 days	freeze-dried powder	35th day	Decreased in body weight and food intake. Decreased in tissue weight of kidney, liver, and adipose tissue. Decreased level of triglyceride, total cholesterol, and glucose in plasma. Increased level of HDL in plasma. Increased level of antioxidant activity in blood.	I. batatas is able to stimulate lipid metabolism.
Nasoetion et al., 2019 [42]	Broiler chicks fed with crude protein diet	25 mL/kg/day and 50 mL/kg/day for 35 days	Aqueous	Weekly for 35 days	Increased growth rate, feed intake and feed efficiency. Decreased level of LDL, total cholesterol, and fat in blood and liver. Increased level of HDL in blood and liver. Decreased level of hepatic lipid metabolism.	Sweet potato extract is able to reduce fat deposition.
Nur et al., 2019 [43]	Zebrafish (Danio rerio) fed with HFD	80 ppm, 120 ppm, and 160 ppm for 40 days	Ethanol	Weekly for 40 days	Increased growth rate, feed intake and feed efficiency. Decreased level of glucose in blood. Decreased level of total cholesterol in plasma. Decreased level of Peroxisome proliferator- activated receptor gamma (PPAR-γ).	Sweet potato extract is able to reduce fat deposition.
Heriwijaya et al., 2020 [44]	White male Wister rats fed with high cholesterol diet	3 cc, 6 cc, and 9cc for 12 weeks	Aqueous	12th week	Decreased level of LDL, triglyceride, and total cholesterol. Increased level of HDL in blood.	Purple sweet potato leaf extract is able to reverse hyperlipidemia condition
Khairani et al., 2020 [45]	Male Mus Musculus mice fed with HFD	0.3 mL/day, 0.5 mL/day, and 1.0 mL/day for 9 weeks	Aqueous	9th week	Decreased level of cholesterol, triglycerides, and LDL in blood. Reduced weight of visceral fats and liver. Inhibition in the elevation of overall body weight. Increased in the lactic acid bacteria colony in gut.	0.3 mL/20 g/bw is the optimum dosage of the extract to exhibit maximum effect.
Ntchapda et al., 2021 [46]	Male Wistar rats fed with HFD	400 mg/kg, 500 mg/kg, and 600 mg/kg for 4 weeks	Aqueous	4th week	Decreased in body weight. Increased level of feces excretion. Decreased level of cholesterol, triglycerides, VLDL-c and LDL in blood. Increased level of HDL in blood. Decreased level of AST, ALT, glucose, and creatinine in serum.	I. batatas is able to reverse hyperlipidemia condition.