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Transient upregulation of circulating Metrnl levels during longitudinal observation of weight loss in LCD (n = 80) and bariatric study cohort (n = 82). Metrnl serum concentrations are significantly elevated 3 months after start of LCD (A) or bariatric surgery (B). In the bariatric patients, there is an initial decline occurring directly upon surgery (3–5 days). LCD, low calorie diet; Metrnl, Meteorin-like protein.
