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Dysregulation of Signaling through Raf-1 in tumor cells (left panel), endothelial cells, and/or pericytes (right panel) that could result in tumor growth and/or angiogenesis by an autocrine mechanism in HCC, and the effect of sorafenib (Sf), The white arrows indicate the effect on intra-cellular signal molecules or pathways. The dotted arrows indicate the effect on cell membrane receptors (Modified from [12]).
