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. 2021 Oct 6;22(19):10774. doi: 10.3390/ijms221910774

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representation of Sorafenib in complex with B-Raf. (A) Ribbon representation of b-Raf in complex with Sorafenib (yellow sticks). The 3-D structure used (pdb code 1UWH) was uploaded from the protein data bank (https://www.rcsb.org/structure/1UWH). (B) zoom from A showing interacting residues (blue sticks) with Sorafenib in the active site of b-Raf. Figure was constructed using the BIOVIA Discovery Studio software (BIOVIA, Dassault Systèmes, [BIOVIA Discovery Studio], [v17.2.0.16349], San Diego: Dassault Systèmes, [2017]).