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. 2021 Oct 6;22(19):10774. doi: 10.3390/ijms221910774

Figure 12.

Figure 12

(A) Chemical structure of Nutlin‒3. (B) Nutlin‒3 inhibits binding of p53 and p73 to MDM2 when combined with DOX and increases p53 and p73 activity in human HCC cell lines (Modified from [109]).