Table 2. Drug resistance mutations in CSF.
| PID | VL (copies/ml) Pl/CSF |
Drug resistance mutation | TFV (ng/ml) Pl/CSF |
FTC (ng/ml) Pl/CSF |
EFV (ng/ml) Pl/CSF |
LPV (ng/ml) Pl/CSF |
RTV (ng/ml) Pl/CSF |
|---|---|---|---|---|---|---|---|
| 0161 | <40/1350 | None detected | 76/3.0 | 445/256 | 1490/4.4 | 3.0/3.0 | 3.0/3.0 |
| 0213 | <40/1330 | V82A/D67N/K70E/L74I/V106M/M184V/G190A | 225/4.9 | 420/153 | 3.0/3.0 | 7730/7.0 | 935/3.0 |
| 0189 | 12802/310 | K65R/V75I/M184V/L100I/K103N/P225H | 82/3.0 | 146/175 | 1990/9.6 | 3.0/3.0 | 3.0/3.0 |
| 0133 | 19551/28250 | M46I/V82A/D67N/K70R/M184V/T215F/K103N/K238T | 19/5.0 | 63/71 | 3.0/3.0 | 14/3.0 | 3.0/3.0 |
| 0183 | 58000/1300 | D67N/M184V/K103N/V106M | 55/3.0 | 229/129 | 2460/3.0 | 3.0/3.0 | 3.0/3.0 |
| 0140 | 254/21370 | K101E | 33/3.0 | 98/123 | 5530/40 | 3.0/3.0 | 3.0/3.0 |
| 0164 | 620/2900 | K101E | 43/3.0 | 518/169 | 4130/8.8 | 3.0/3.0 | 3.0/3.0 |
| 0168 | 936/3030 | None detected | 56/3.0 | 286/196 | 2370/3.5 | 3.0/3.0 | 3.0/3.0 |
| 0172 | 24000/801 | None detected | 3.0/3.0 | 3.0/3.0 | 3.8/3.0 | 3.0/3.0 | 3.0/3.0 |
PID: participant ID. Pl: plasma. LPV: lopinavir. RTV: ritonavir. Limit of detection 40 copies/mL for VL and 3.0 ng/mL for antiretroviral drugs.