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Active PAK protects NIH 3T3 cells from apoptosis induced by ceramide. NIH 3T3 cells stably expressing PAK-T423E or PAK-K299R in a tetracycline-dependent manner, or vector control cells (Co), were starved for 6 h and incubated with or without 50 M C2-ceramide for 6 h. Floating and attached cells were collected and stained with trypan blue. Results shown are the mean ± standard error of the mean (n = 3).
